Historical-critical scholars since the 19th century have rightly identified the Babylon of Revelation 17-18 as ancient Rome. In their search for the historical context of the oracle against Rome and its empire, readers attuned to Revelation’s reuse of early prophecies have focused on the recollection of oracles against Babylon in Isaiah 47 and Jeremiah 25 and 51-52. Supplementing the Babylon-cum-Rome interpretation, commentators have also recognized prophecies against Samaria and Jerusalem their harlotry in Hosea 4 and Ezekiel 16 and 23, and against Tyre and its mercantile empire in Isaiah 23 and Ezekiel 26-28. The historical-critical impulse to refute medieval and Reformation-era interpretations has over-emphasized Babylon in our interpretation of Revelation’s oracle against Rome. The field, correspondingly, has paid insufficient attention to subtle allusions to the destructions of Nineveh, Edom, and Sodom in Revelation 17-18. Through a cluster of brief allusions, Revelation depicts Rome as being a “Great City” like Nineveh through recollections of oracles against the Assyrian imperial capital. Similarly, Revelation evokes the internecine conflict with Edom and God’s vengeance in Isaiah 34, Obadiah, Psalm 137 and Lamentations 4. Sodom appears as Rome’s Scriptural antecedent by considering how, even if Sodom appears only faintly in Revelation 17-18, Revelation reused prophecies against Jerusalem, Babylon, and Edom that themselves allude to Genesis 18-19. These neglected allusions do more than supply biblical language for Revelation’s oracle against Rome. Rome is more than Babylon: it is the summation of all the cities and kingdoms that God has already defeated. In a battle for prophetic authority regarding acculturation to Rome and imperial cults, the author establishes through both overt and subtle allusions that Rome is like Babylon, Jerusalem, Samaria, Tyre, Nineveh, and Edom. In doing so, he gives his oracle the authority of his prophetic predecessors. Like the cities and nations which preceded it, Rome will fall; God will destroy the Great City. Those who, like Balaam and Jezebel, would align themselves with the Roman Empire are consigning themselves to destruction.